Not all women with CIN respond to HPV vaccine, New study claims

HPV causing cervical cancer
HPV causing cervical cancer
Azadi Ka Amrit Mahoutsav

Not all women with CIN respond to HPV vaccine, New study claims

Faruque Ahamed

KOLKATA, 9 OCTOBER – Multiple sexual partners and early sexual debuting predispose to Human Papilloma Virus (HPV) that causes cancer, according to oncologists. Other than cervical cancer, HPV may also cause cancer in male and female external  genitalia. Currently, vaccination efforts against HPV worldwide have reduced the  incidence of cervical cancer. HPV vaccination protects against cervical neoplasia, which  is the pre-cancerous form.

The vaccination induces local immune response, which kills the  neoplastic cells. There are about 100 different types of HPV; of these, about 13 are cancer causing,  including HPV16 and HPV18. HPV causes cancer of the cervix, which is the outward part of  the uterus. Prior to frank cancer, pre-cancerous lesions may occur, which are called Cervical Intraepithelial Neoplasia (CIN).

The commonest symptom of CIN is bleeding and  pain after sexual contact. Surprisingly, in a new study, finding suggests that not all women with Cervical  Intraepithelial Neoplasia will respond positively to HPV vaccination. Using sophisticated  analysis, the researchers led by Dr. Rahul Ravilla at the University of Arkansas for  Medical Sciences, in their study have helped establish the methods to identify the at- risk women who would not respond to the protective effects of HPV vaccine. HPV vaccine is a new therapeutic vaccine developed by the team is different from the  routine vaccine that is administered for protective vaccination, according to Dr Ravilla.  There might be chances of rise in number of sex-related transmitted cancer cases  following the recent developments in the country, felt city doctors fearing that men sex  with men (MSM) may come to forefront.

“We are also concerned with the sex-related carcinogenic ailments. With regular spurt in  number of cancer cases in the country there might be more chances of more reports of the  deadly disease if someone has unsafe sex with multiple partners. We have to keep watch on  developments if we get any such cases,” said oncologist Dr Ashish Mukherjee, medical  director of the Netaji Subhas Bose Cancer Research Institute in the city.  “There might be chances more transmissions of HPV owing to some recent developments in  connection with sexual relationships with more than one paerners,” felt Dr Goutam  Mukherjee, a senior onco surgeon in the city.  “But everything can be prevented if consenting adults go for sex taking safety  measures,” said a senior oncologist associated with a premier private cancer hospital in  the Rajarhat area. 



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