Not all women with CIN respond to HPV vaccine, New study claims
KOLKATA, 9 OCTOBER – Multiple sexual partners and early sexual debuting predispose to Human Papilloma Virus (HPV) that causes cancer, according to oncologists.Other than cervical cancer, HPV may also cause cancer in male and female external genitalia. Currently, vaccination efforts against HPV worldwide have reduced the incidence of cervical cancer. HPV vaccination protects against cervical neoplasia, which is the pre-cancerous form.
The vaccination induces local immune response, which kills the neoplastic cells.There are about 100 different types of HPV; of these, about 13 are cancer causing, including HPV16 and HPV18. HPV causes cancer of the cervix, which is the outward part of the uterus. Prior to frank cancer, pre-cancerous lesions may occur, which are called Cervical Intraepithelial Neoplasia (CIN).
The commonest symptom of CIN is bleeding and pain after sexual contact.Surprisingly, in a new study, finding suggests that not all women with Cervical Intraepithelial Neoplasia will respond positively to HPV vaccination. Using sophisticated analysis, the researchers led by Dr. Rahul Ravilla at the University of Arkansas for Medical Sciences, in their study have helped establish the methods to identify the at-risk women who would not respond to the protective effects of HPV vaccine.HPV vaccine is a new therapeutic vaccine developed by the team is different from the routine vaccine that is administered for protective vaccination, according to Dr Ravilla. There might be chances of rise in number of sex-related transmitted cancer cases following the recent developments in the country, felt city doctors fearing that men sex with men (MSM) may come to forefront.
“We are also concerned with the sex-related carcinogenic ailments. With regular spurt in number of cancer cases in the country there might be more chances of more reports of the deadly disease if someone has unsafe sex with multiple partners. We have to keep watch on developments if we get any such cases,” said oncologist Dr Ashish Mukherjee, medical director of the Netaji Subhas Bose Cancer Research Institute in the city. “There might be chances more transmissions of HPV owing to some recent developments in connection with sexual relationships with more than one paerners,” felt Dr Goutam Mukherjee, a senior onco surgeon in the city. “But everything can be prevented if consenting adults go for sex taking safety measures,” said a senior oncologist associated with a premier private cancer hospital in the Rajarhat area.